Tuberculosis causes, symptoms , diagnosis and treatment 2023

Tuberculosis, commonly known as TB, is an infectious disease that primarily affects the lungs. It is caused by the bacterium Mycobacterium tuberculosis and can spread through the air when an infected person coughs, sneezes, or talks. TB can also affect other parts of the body, such as the kidneys, spine, and brain.

TB is a serious global health problem, with an estimated 10 million people worldwide falling ill with the disease each year. It is a leading cause of death from infectious diseases, with an estimated 1.4 million deaths annually.

Tuberculosis

Causes of Tuberculosis

Tuberculosis (TB) is caused by a bacterium called Mycobacterium tuberculosis. This bacterium is spread through the air when an infected person coughs, sneezes, or talks. When a person inhales the bacteria, they can settle in the lungs and begin to multiply, causing infection.

TB is a contagious disease, but not everyone who is infected with the bacteria will develop active TB disease. In some cases, the bacteria can remain dormant in the body for years without causing symptoms. This is known as latent TB, and it is not contagious. However, if the immune system becomes weakened for any reason, such as illness, malnutrition, or aging, the bacteria can become active and cause TB disease.

Factors that increase the risk of developing active TB disease include:

  1. Weakened immune system: People with weakened immune systems, such as those living with HIV/AIDS or taking immunosuppressive medications, are at a higher risk of developing active TB disease.
  2. Age: TB is more common in older adults, as the immune system weakens with age.
  3. Close contact with an infected person: People who have close contact with someone who has active TB disease are at a higher risk of becoming infected.
  4. Poor living conditions: Overcrowding, poor ventilation, and inadequate nutrition can increase the risk of TB transmission.
  5. Substance abuse: People who abuse drugs or alcohol are at a higher risk of developing active TB disease, as substance abuse can weaken the immune system.

In conclusion, TB is caused by the bacterium Mycobacterium tuberculosis, which is spread through the air when an infected person coughs, sneezes, or talks. Factors that increase the risk of developing active TB disease include a weakened immune system, age, close contact with an infected person, poor living conditions, and substance abuse. Understanding these risk factors can help to prevent the spread of TB and improve the overall health and wellbeing of affected individuals.

Symptoms of TB can vary depending on the severity of the infection and the part of the body affected. Common symptoms include persistent cough, chest pain, fever, night sweats, fatigue, and weight loss. TB can be latent, meaning that the bacteria are present in the body but do not cause symptoms, or active, meaning that the bacteria are actively causing symptoms.

Symptoms of Tuberculosis

Tuberculosis (TB) can affect various parts of the body, but the most common form of the disease is pulmonary TB, which affects the lungs. The symptoms of TB can vary depending on the severity of the infection and the part of the body affected.

Symptoms of pulmonary TB include:

  1. Persistent cough: A cough that lasts for more than two weeks and produces thick, sometimes bloody phlegm or sputum.
  2. Chest pain: Pain or discomfort in the chest that may worsen with deep breathing, coughing, or laughing.
  3. Fatigue: Feeling tired and weak, even after getting enough rest.
  4. Night sweats: Profuse sweating at night, which may require changing clothes or bedding.
  5. Unintentional weight loss: Losing weight without trying, and experiencing a loss of appetite.
  6. Fever: Low-grade fever, usually in the afternoon or evening.

Symptoms of TB that affects other parts of the body can include:

  1. Back pain: Pain in the lower back or spine, which may worsen with movement.
  2. Urinary problems: Painful urination, blood in the urine, or frequent urination.
  3. Headaches: Pain or pressure in the head, which may be severe.
  4. Swelling: Swelling in the neck or other areas of the body, such as the legs or abdomen.

It is important to note that some people with TB may not experience any symptoms at all, especially those with latent TB infection. However, even without symptoms, a person with latent TB can still develop active TB disease if the immune system becomes weakened.

If you experience any of the symptoms of TB, it is important to seek medical attention immediately. Early diagnosis and treatment can help prevent the spread of TB and improve outcomes for affected individuals.

Diagnosis of Tuberculosis

Diagnosis of tuberculosis (TB) involves several tests and procedures to confirm the presence of the TB bacteria and determine the severity of the infection. Some common methods used for TB diagnosis include:

  1. Tuberculin skin test: Also known as a Mantoux test, this involves injecting a small amount of purified protein derivative (PPD) under the skin of the forearm. A positive result indicates that the person has been exposed to the TB bacteria, but it does not confirm active TB disease.
  2. Blood tests: There are several blood tests that can detect the presence of TB antibodies, including the interferon-gamma release assay (IGRA). These tests are used to diagnose both latent TB and active TB disease.
  3. Chest X-ray: A chest X-ray can detect abnormalities in the lungs that may be caused by TB infection. It is often used in combination with other tests to diagnose active TB disease.
  4. Sputum culture: A sample of sputum, or mucus from the lungs, is collected and analyzed in a laboratory to confirm the presence of TB bacteria.
  5. Molecular tests: Molecular tests, such as the nucleic acid amplification test (NAAT), can detect the genetic material of the TB bacteria in sputum samples. These tests are faster and more accurate than traditional culture-based tests.
  6. Biopsy: In rare cases, a biopsy may be necessary to diagnose TB that affects other parts of the body, such as the lymph nodes or kidneys.

It is important to note that TB diagnosis can be challenging, as the symptoms can be similar to those of other respiratory illnesses. Therefore, it is important to seek medical attention if you experience any symptoms of TB, especially if you have been in close contact with someone who has Tuberculosis or have traveled to areas with high Tuberculosis prevalence. Early diagnosis and treatment can help prevent the spread of Tuberculosis and improve outcomes for affected individuals.

Diagnosis of Tuberculosis involves a combination of medical history, physical examination, and diagnostic tests. Tests may include a skin test, blood test, chest X-ray, and sputum test, which involves collecting a sample of mucus from the lungs and testing it for the presence of the bacteria.

Treatment of Tuberculosis

The treatment of tuberculosis (TB) typically involves a combination of medications that are taken for several months to effectively kill the TB bacteria and prevent the development of drug-resistant strains. The specific medications used and the duration of treatment depend on the type of Tuberculosis infection and the severity of the disease.

The most commonly used medications for treating TB include:

  1. Isoniazid (INH)
  2. Rifampin (RIF)
  3. Ethambutol (EMB)
  4. Pyrazinamide (PZA)

These medications are usually taken daily for at least six months to effectively treat active TB disease. However, in some cases, treatment may need to be extended to nine or 12 months.

For drug-resistant TB, the treatment may involve the use of multiple medications for a longer duration, up to two years or more.

It is important to take the medications exactly as prescribed, for the entire duration of the treatment, even if you start feeling better before the course is completed. Missing doses or stopping treatment early can lead to the development of drug-resistant strains of TB, which are much more difficult to treat.

In addition to medication, people with TB may also need supportive care, such as nutritional supplements, to help boost their immune system and aid in recovery. Regular monitoring and follow-up with a healthcare provider are also important to ensure that the treatment is effective and to prevent the spread of TB to others.

It is important to note that TB is a highly contagious disease and can be spread through the air when an infected person coughs, sneezes, or talks. Therefore, it is important to practice good hygiene, such as covering your mouth and nose when coughing or sneezing, and staying home when you are sick with TB, to prevent the spread of the disease to others.

Treatment of TB involves a combination of antibiotics taken over several months. It is important to complete the full course of treatment, even if symptoms improve, to prevent the development of drug-resistant strains of the bacteria.

Prevention of TB involves a combination of measures, including vaccination, early diagnosis and treatment of active TB, and infection control measures such as good ventilation and wearing masks to prevent the spread of the disease.

Foods That helps in Tuberculosis

Eating a healthy and balanced diet can play an important role in supporting the immune system and aiding in recovery from tuberculosis (TB). Here are some foods that may be helpful:

  1. Protein-rich foods: Foods that are high in protein, such as lean meats, poultry, fish, beans, lentils, and tofu, can help support the immune system and promote tissue repair.
  2. Fruits and vegetables: A diet rich in fruits and vegetables can provide essential vitamins and minerals, such as vitamin C and beta-carotene, that can help support immune function and promote healing. Good choices include citrus fruits, berries, leafy greens, sweet potatoes, and carrots.
  3. Whole grains: Whole grains, such as brown rice, whole wheat bread, and oatmeal, can provide essential nutrients and fiber to support overall health.
  4. Nuts and seeds: Nuts and seeds, such as almonds, walnuts, pumpkin seeds, and chia seeds, can provide essential fatty acids and protein to support immune function and promote healing.
  5. Probiotic-rich foods: Foods that are rich in probiotics, such as yogurt, kefir, kimchi, and sauerkraut, can help support gut health and boost the immune system.

It is important to note that certain foods may interact with TB medications and may need to be avoided or consumed in moderation. It is best to consult with a healthcare provider or a registered dietitian for personalized dietary advice based on your individual needs and medical history.

TB is a complex disease that requires a coordinated global effort to control and eliminate. This includes investment in research to develop new drugs and vaccines, as well as efforts to improve diagnosis, treatment, and prevention. With continued efforts, it is possible to reduce the global burden of TB and improve the health and wellbeing of people affected by this disease.

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